하병조 Byung-jo Ha

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조완구 Wan-goo Cho

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지홍근 Hong Geun Ji , 윤경로 Kyung Rho Yun , 류창덕 Chang-duck Ryu , 서봉석 Bong Seok Seo

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Colloid refers to dispersed particles of solid or liquid having diameters of 10^-5 to 10^-7cm, among which colloidal silver is produced by electrolysis. Colloidal silver of various concentrations according to charge and time were formed, antimicrobial activity of colloidal silver was measured. And, the optimum conditions for emulsion were determined by changing the concentration of coloidal silver. Also, the stability of the emulsion was measured by zeta potential and chroma meter by applying colloidal silver to creams(W/S, O/W, MLV)

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김완주 Wan Ju Kim , 유병수 Byung Soo Ryu , 전병훈 Byung Hoon Chun , 이정섭 Jung Sup Lee , 박상대 Sang Dai Park , 김인호 In Ho Kim , 최수봉 Soo Bong Choi , 박종군 Jong Kun Park

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We have studied the effects of red ginseng root extract on the decrease of UV-induced genotoxicity in cultured NIH3T3 cells. The increase in survival and the recovery from DNA synthesis inhibition in UV-irradiated cells as a funtion of normal medium incubation time was potentiated by the presence of the ginseng extract. The extract also increased the UV-induced excision repair as determined by unscheduled DNA synthesis. The amount of UV-induced DNA single strand breaks that are accumulated by polymerase inhibitors was signifcantly increased by the presence of the extract. These results suggest that the red ginseng extract activates the incision/excision step of UV-induced repair and could be used as a reagent for protecting UV-induced genotoxicity and cytotoxicity.

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차재영 Jae Young Cha , 유병수 Byung Soo Ryu , 조철오 Cheol O Joe , 김인호 In Ho Kim , 박민우 Min Woo Park , 황계훈 Jae Hoon Hwang , 김주덕 Ju Duk Kim , 박종군 Jong Kun Park

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We have studied the effects of red ginseng root extract on the decrease of MMS-induced genotoxicity in cultured NIH3T3 cells. The increase in survival and the recovery from DNA synthesis inhibition in MMS-treated cells as a funtion of normal medium incubation time was potentiated, at a rate higher than those in UV-irradiated cells, by the presence of the ginseng extract. The extract also increased the MMS-induced excision repair as determined by unscheduled DNA synthesis. The amount of MMS-induced DNA single strand breaks that are accumulated by polymerase inhibitors was increased, but at a rate lower rate than in UV-induced strand break, by the presence of the extract. These results suggest that the red ginseng extract increase MMS-induced repair and could be used as a reagent for protecting alkylating agent-induced genotoxicity and cytotoxicity.

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서경희 , 신계호

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김범준 Beom-jun Kim , 김정하 Jeong-ha Kim , 김현포 Hyun-pyo Kim , 허문영 Moon-young Heo

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Inner nutshell of Castanea crerata(chestnut) has been used as an anti-aging and anti-wrinkle agent from the ancient time in east Asia. In order to develop new anti-aging and anti-wrinkle, ethanolic extract of inner nutshell of Castanea crenata(Cor-285) was prepared and various biological activities were evaluated. Cor-285 showed potent anti-oxidant activity. Especially, Cor-285 possessed potent free radical scavenging activity in vitro(lC₅₀:7.6㎍/ml) compared to gallic acid(IC₅₀:12.5㎍/ml). Cor-285 showed the preventive effect against UV-induced cytotoxicity of fibroblast at concentration of 25-250㎍/ml. When Cor-285 was evaluated for its anti-allergic activity, it effectively inhibited histamine release from mast cells induced by compound 48/80(86% inhibition at 10mg/ml). The inhibitory activity was stronger than that of glycyrrhizinate. Cor-285 also showed in vivo inhibition against delayed hypersensitivity as well as croton-oil induced ear edema in mice when topically applied. These results strongly suggest that Cor-285 may reduce immunoregulatory/inflammatory skin trouble. From the attempts to isolate the scavenger, were isolated. In a clinical trial of twenty healthy volunteers with aged skin, 6 weeks application of Cor-285(3% cream) decreased wrinkle about 26% and increased moisturizing 20% on the skin. All of these results indicate that Cor-285 may be an effective anti-aging and anti-wrinkle agent.

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