김인영 In-young Kim , 서봉석 Bong-seok Seo , 전영환 Young-hwan Jeon , 한영준 Young-jun Han , 박성순 Seong-soon Park

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Abstract

In this context, it should be mentioned that multilamellar vesicles can be prepared with the main compounds of the intercellular lipids, ceramides, cholesterol, cholesteryl ester, squalane, lecithin, wax ester by effect of the wetting. We investigated properties formation of MLV with use of the AHAsomes and Microfluidizer. The multilamellar vesicles are formed merely adding polyol and water phase, followed with the microfluidizer. Formation of a practically pure AHAsomes system, containing the active ingredients directly incorporated without need for preservatives. There were very good encapsulated properties of the active ingredients whether hydrophilic(malic acid, tartaric acid, lactic acid, allantoin, urea) and hydrophobic(vitamin-I acetate, vitamin-A palmitate). Optimum condition (ormatiom of MLV was passed three times in the microfluidizer, particle size of the vesicles should be within range 50-523nm (mean=163.5nm). As application, It was compared that horny layer of the sole of foots removal with the general OM emulsion and the AHAsomes cream. There was used for three months, those got recovery wrinkles about 151.8% and elasticity three times more the AHAsomes than O/W emulsions, It was confirmed with the Image Analyzer and the Cutometer.

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오주영 Joo-young Oh , 한창규 Chang-gew Han , 조춘구 Choon-ku Zhoh

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Abstract

This study was investigated to search for the effects of the structure of each component in four-component O/W microemulsion system on its formation region, droplet size and stablilty. The results was that the more number of OH site, the shorter carbon chain length of polyol, the larger formation region of microemulsion was showed. The small microemulsion droplet was obtained on condition that the polatry of oil was large and carbon chain length of hydrophobic group of surfactant was long. In using satrated hydrocarbon (such as liquid paraffin, squalane) as dispersed phase, the stability of microemulsion was better than aromatic oil phase.

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하병조 Byung-jo Ha , 이옥섭 Ok-sub Lee , 이충남 Choong-nam Lee , 이윤식 Yoon-sik Lee

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Abstract

Chitosan microcapsules and microbeads were prepared by W/O emulsion method, and their morphologies were observed through SEM. The microcapsules have sk-in layer of 8 μm and 250 μm of mean diameter, The swelling test showed higher swelling ability in protic solvents than in aphotic solvents. After containing moth-yl violet in the microcapsules, the release patterns were investigated. The results sho wed that the addition of Iysozyme in pH 5.1 acetate buffer accelerated the re-lease rate. In case of the microbeads, the mean diameter was about 70 μm. The surface of the microbeads showed porous structures. The swelling ability of the beads revealed two times higher than the one of the microcapsules.

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오선진 Sun-jin Oh , 김진준 Jin-jun Kim , 김태헌 Tae-hyun Kim , 김명옥 Myoung-ok Kim , 강세훈 Se-hoon Kang

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Abstract

We have recently developed a novel in vitro SPF evaluation method with a high correlation coefficient (r=0.93) to in vivo SPF values(test sunscreen formulas : cress m, foundation). In this method, the in vitro SPF value was determined by the ratio of the time taken to achieve the minimal erythema dose with and without the sunscreens applied. We also reviewed the dilution and thin-layer methods for in vitro SPF evaluation, and investigated the relationship between irradiance(3x10^-3 2.5x 10^-5W/cm²) and the degree of erythema. The degree of erythema was similar if t he radiation exposure(40mJ/cm²) was kept constant. It was obtained more than 0.90 correlation coefficient when it was compared the results by our new method with those from SPF-290 analyzer (Optometries, U.S.A.).

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De-pei Tan , Quing-wei Wang , Seong-joon Moon , Young-guk Cho , Eui-dong Son , Woo-young Lee

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Abstract

The effect of natural products(drug 1，drug 2) on hair growth of frontal scalp of ten stumptailed macaques was investigated in period of 12 months. Drug 1 conteins extracts of Angelica gigantis Radix etc. and drug 2 conteins extracts of Corni Fructus, etc. Photographs of close view of the frontal scalp were taken once every month and folliclogram analysis has been done at pretretment and on 5th, 10th and 12th month after treatment. Drug 1 showed only slight effect or no effect on hair growth and drug 2 exhibited a significant degree of hair regrowth, but the control group exhibited a definite degree of regrowth and increasing density of vellus hair. Also, the physiological parameters, such as body weight, blood pressure, heart rate, serum levels of androgens, hematological measures during the treatment of drug 1，drug 2，and vehicle, were within normal limits. It indicates the drug 2 is the possible appearence of new summit of hair growth.

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한종섭 Jong-sub Han , 김종일 Jong-il Kim , 김의 Eui Kim , 김형진 Hyung-jin Kim , 강세훈 Se-hoon Kang

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Abstract

In this study, the relationship between partition coefficients(K_w) of oils and antimicrobial effects Ivas investigated. The antimicrobial activity of paraben has been known to be controlled by the concentration of the paraben in the aqueous phase. The concentration of paraben in the aqueous phase was measured by the UV/VIS spectrophotometer at the wavelength of 256nm. It was found that the hydrocarbon oils and silicone oils had the lowest K_w value(<1.0) among the tested oils. Also, the emulsions which were made of oils having low K_w values had a good antimicrobial effects. Thus, the cosmetic safety against microorganisms could be improved by using the oils which have low Kw values.

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이종철 Jong-chul Lee , 한창규 Chang-gew Han , 조춘구 Choon-ku Zhoh

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Abstract

This study was undertaken to see the effect of the addition of residential sewage to cosmetic plant wastewater on the aeration time for COD stabilization of the mixture in a bioreactor. Various range of mixing-ratio samples were tested to find the optimal mixing ratio. The combined result of measured COD and the minimum aeration time was desirable when the sewage portion was 80%. It was found that the addition of residential sewage to cosmetic plant wastewater itself reduced the measured COD of the mixture without any further treatment. And during the aeration COD was reduced with increasing the portion of the sewage. These results show that the aeration time for COD stabilization can be reduced by pro-mixing of residential sewage and the cosmetic plant wastewater.

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최종근 Jong-keun Choi , 노경원 Kyung-won Ro , 허찬우 Chan-woo Hur , 김진우 Jin-woo Kim

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Abstract

To confirm the usefulness of partial least-squares(PLS) and multiple scattering correction(MSC) method for quantitation of surfactants in [quantitative methods using FT-lR, reconsitituted mixtures of LAS, MES and ELA-9 were tested. Each mixture was dissolved in 50% EtOH, dried, and applied to the KBr cell. From the IR spectra of these mixture, the variance spectrum was obtained. After repeated calibrations for the various regios of this spectrum, we found that 1245-1130cm^-1 and 1070-1010cm^-1 showed the strong correlation with each component of the sample mixture: all the correlation coefficients were 1.000 and quantitative errors did not exceed 0.32%. From this result, we concluded that PLS method and MSC method are very useful and can be successfully applied to Quality control.

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